Results related to a specific entity

Note this article relates to a legacy functions. Its capabilities are now covered by get_resources().

Introduction

The query_resource_all() function enables you to retrieve all records for a particular resource using a search term. If you want to limit the records returned to a specific institution, this requires additional arguments.

query_resource_combination() uses a list of defined combinations of resources (gtr_combinations) as well as an id argument to refine the records and only include those that match your resource combination and id.

Process

1. First you will need to check gtr_combinations to identify what resource combinations are required. The first resource in these combinations is what we will be filtering against using the id argument, and the second resource are the records that will be returned (eg. the “organisation project” combination will return all projects for a specific organisation, where the organisation is determined by the id).

2. Next you need to retrieve the id that will be used to filter the resource. This can be done by using the query_resource_all function and making note of the id of the relevant record.

3. You can now use query_resource_combination function with the two resources found in gtr_combinations and the id retrieved from query_resource_all.

Example

You want to return all projects linked to the University of Exeter.

library(gtR)

exeter_id <- query_resource_all(
  resource = "organisation",
  search_term = "Exeter"
  )

id <- "961756BF-E31F-4A13-836F-0A09BA02385C"

data <- query_resource_combination(
  resource = "organisation",
  output = "project",
  "961756BF-E31F-4A13-836F-0A09BA02385C",
  size = 10
)

data
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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/5760B248-DF81-42EA-95AD-AECFDD9F8D89, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/0AB91C9C-A853-4DAA-9BE7-E2B7972B2788, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/FAE9F588-2E6B-4982-830A-2268BC4911F0, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/AEBD10CD-94A2-4D56-817D-9EF78C184065, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/ACDC18D8-A1E2-473F-A890-291162881EB7, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/22D6F2A3-B32A-4DB6-9195-AF91CF4DAFD4, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/D2C1682B-0FFB-42CE-BC09-7E1159D1E2F3, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/6A286186-793E-4637-84FC-28222FA59A18, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/3C8AB389-D42D-4430-97EC-6D3CF9731089, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/0E047457-4881-48FD-B831-EE1ED085ED02, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/persons/C3CEA9CD-B477-43F5-8D10-0DC2C014DC9F, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/E89C3602-0FB4-4044-A918-58966B8A10B2, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/318B5D98-4CB4-4B10-A876-08FC93071A56, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/DFE9B366-8CEB-4538-9328-A98FEFA2C62C, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/687DA070-DC7E-4707-A161-C645722E7965, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/1932D756-ACAD-4551-B8CE-67F2B58E72F9, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/99A20F70-F6B7-43DE-94E4-7004FAE6291E, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/D7BAD270-7EC9-4FDA-AF70-2AADFD3C4445, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/D15B1E41-E720-44FE-AA43-ADADA16272A5, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/79F35CCF-D41E-427E-9F05-1AC8502BD798, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/8A0FC07A-04CD-4F7A-9095-1D2E6C1D918F, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/E114F0B4-0B6C-4E3A-9066-2CC60A83A311, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/5E9E5F30-A127-4243-AB12-B19B7A50D0E7, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/C589F66D-F237-43D5-B128-E2317E9B3AEA, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/4A348A76-B2D0-4DDD-804A-CE735A6D3798, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/1F5352DA-4C77-4165-902D-BBDC632C72BA, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/961756BF-E31F-4A13-836F-0A09BA02385C, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/5E2B04DD-4A03-45ED-9892-61C5CCB8AC68, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/EB68FB1A-FD15-4CC9-9219-7C541C7E0405, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/organisations/99A20F70-F6B7-43DE-94E4-7004FAE6291E, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/funds/3935EAAD-A40F-4131-8361-CC984D22BBF3, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/outcomes/keyfindings/B99CF86B-8B8B-4F79-83D1-D974E4BA0D60, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/outcomes/collaborations/CF470E13-7631-4552-A6B7-902843CEBF31, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/outcomes/collaborations/B921D927-1E93-440B-B679-D6F31D86F78B, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/outcomes/collaborations/2853ED6A-7BAE-4694-9E13-623393AC2AC5, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/outcomes/collaborations/C63E6711-3EE6-4D34-8FDB-D3C88620CE69, http://internal-gtr-tomcat-alb-611010599.eu-west-2.elb.amazonaws.com:8080/gtr/api/outcomes/collaborations/7CE979D6-F4E0-4414-96ED-2BDFED136D31, 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#> 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     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#> 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     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#> 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    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#>                                                                                                                                     title
#> 1                           Forecasting Rainfall exploiting new data Assimilation techniques and Novel observations of Convection (FRANC)
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#> 3                                                       Identifying Genetic Risk for Late-onset Alzheimer's Disease: The GERAD Consortium
#> 4                                                                                                     Management of Emerging Contaminants
#> 5                                                               Monte Carlo simulation of Raman scattering in heterogeneous breast tissue
#> 6                                                          Does metformin reduce excess birthweight in offspring of obese pregnant women?
#> 7                                                                                                              DTA - University of Exeter
#> 8                                                                                       Flow-driven Instabilities of the Sun-Earth System
#> 9                                                  CORNERSTONE: Capability for OptoelectRoNics, mEtamateRialS, nanoTechnOlogy aNd sEnsing
#> 10                                                                Developmental Disorders: From Diagnosis to Mechanism via Cis-Regulation
#>    status  grantCategory leadFunder             leadOrganisationDepartment
#> 1  Closed Research Grant       NERC                            Meteorology
#> 2  Active Research Grant       AHRC           Institute of Health Research
#> 3  Closed Research Grant        MRC                     School of Medicine
#> 4  Active    Studentship      EPSRC Engineering Computer Science and Maths
#> 5  Active    Studentship      EPSRC Engineering Computer Science and Maths
#> 6  Closed     Intramural        MRC                                   <NA>
#> 7  Closed Training Grant      EPSRC          Research Grant Administration
#> 8  Closed     Fellowship       STFC                                Physics
#> 9  Closed Research Grant      EPSRC  Optoelectronics Research Centre (ORC)
#> 10 Active     Intramural        MRC                                   <NA>
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#> 1                                                                                                                                                                                                                                                                                                                     Brief periods of intense rainfall can lead to flash flooding with the potential to cause millions of pounds of damage to property, and to threaten lives. Accurate flood warnings even just a few hours ahead can allow preparations to be made to minimize damage. In order to improve the prediction of these events, more accurate forecasts of heavy rainfall are needed, which can then be used to inform flood prediction and warning systems. The UK Met Office is developing a new numerical weather prediction system with the goal of improving severe weather forecasts. This is a computer model that solves mathematical equations representing atmospheric motions and other physical processes such as cloud formation, with a horizontal grid spacing of 1.5km. This allows a more accurate representation of fine-scale features and explicit representation of storms, but the results are still dependent on the accuracy of the starting conditions or initial data describing the current state of atmospheric variables such as winds, pressure, temperature and humidity. Initial conditions are usually estimated using a sophisticated mathematical technique known as data assimilation that blends observations with model information, taking account of the uncertainties in the data. In this project, we propose fundamental research to reduce initial condition errors. The work will be carried out in a partnership between the Universities of Reading, Surrey and the Met Office. \n\nWe plan to investigate ways of extracting the maximum information from weather radar observations of precipitation and moisture in the lower parts of the atmosphere. Although rainfall is usually well observed by weather radar, severe precipitation can cause the radar beam to lose energy, and thus the weaker returned signal may be misinterpreted, giving a lower rain-rate than in reality. We will develop algorithms to correct for this and other problems caused by severe rainfall. Recently, we have also developed techniques to infer humidity information about the lower atmosphere, and we plan to optimize the method and investigate the observation error characteristics, to prepare for this data to be assimilated by the Met Office. \n\nOne of our goals is to use observations to provide information on the small scales without degrading the large scale weather patterns, which are themselves likely to be accurate. However, currently much of the small scale observational information is being lost by ignoring correlations between observation errors. We will develop a generic approach for treating observation correlations for a range of observation types. We will investigate mathematical methods that both capture the maximum amount of information contained in the observations, while still being practical for operational computations, which have to take place within a limited time frame. \n\nAnother goal is to develop innovative ways of treating moist processes that are largely absent from present-day assimilation systems. We plan to design and test efficient and effective ways of assimilating moisture information that respect the intricate dynamical and physical relationships that operate in the atmosphere. If successful, such new approaches will allow better use of cloud and rain affected observations than at present.\n\nPredicting convective rain is made harder by the fact that some events are inherently unpredictable, even with good data assimilation and models, due to their high sensitivity to even small errors in the initial conditions. Further studies will be made to look at the dynamical reasons for the low predictability of such events using diagnostics derived from models and observations.
#> 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       This study addresses two urgent challenges. Firstly, providing COVID-19 (CV-19) information for those with cognitive impairment, specifically people with dementia in care homes. Secondly, alleviating social isolation and loneliness in care homes by providing creative activities that support wellbeing for people with dementia, especially, in the context of long-term CV-19 lockdown and restrictions. \n\nThis project will produce, distribute and evaluate CV-19 culture boxes incorporating pandemic guidance with creative activities to support health and wellbeing and alleviate social isolation and loneliness for people with dementia in care homes. \n\nThe team will work with the Geller Institute of Ageing and Memory (IAM), stakeholders including people with dementia, staff and family carers and allied professionals, including BAME representatives, to co-design culture boxes with artists. These will be delivered weekly for 3 months (then repeated, updated, for 12 months). Each will contain multisensory materials (subject to health and safety guidance) suitable for diverse populations that: provide information about CV-19 transmission and prevention, with creative resources including music and art activities that are simple to implement and offer stimulation and enrichment. The weekly delivery aims to reinforce public health messaging and to mimic regular activities in care homes. \n\nThe National Activity Providers Association (NAPA) will support distribution via their network of 3000 members. The project will be evaluated using Participatory Action Research (PAR). All resources will be archived via the NAPA website ensuring that they are widely available. Dissemination includes an art exhibition, conferences, educational presentations, and a peer-reviewed paper.
#> 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Alzheimer?s disease (AD) is the most common form of dementia whose numbers will double in the next generation resulting in over one million sufferers in the UK alone. It is vital we understand the causes of AD quickly to allow the development of preventative and therapeutic interventions. We have good evidence that genes play significant roles in AD development and that there are several remaining to be found. This research study will use new technological advances to test the influence of every human gene on the risk of developing AD. The success of this approach depends on using very large samples of AD cases and controls. This study is the largest genome-wide association study (GWAS) of AD world-wide and is anticipated to identify 20 new risk genes and disease pathways AD risk genes pinpoint primary biological processes which trigger disease development.
#> 4  The Government of India's Central Pollution Control Board (CPCB), state that 62% of India's wastewater is disposed of untreated. In addition to conventional pollutants, wastewater contains a cocktail of emerging contaminants from municipal and industrial sources. Emerging contaminants can be defined as naturally occurring, synthetic or anthropogenic chemicals/substances which are not regularly monitored and these substances have a negative impact on the environment and human health. Pharmaceuticals, personal care products and endocrine disrupting chemicals are the most common classed categories of emerging contaminants posted within the literature [1]-[3]. India is the world's 3rd largest manufacturer of pharmaceuticals with exports to over 65 countries [4]. India's pharmaceutical exports in 2016/2017 reached US$ 16.8 billion and is expected to grow by 30% over the next three years [5]. Pharmaceutical companies in India are discharging their waste into the water systems and current wastewater treatment plants are unable to remove these emerging contaminants. \nWastewater treatment plants were originally not designed to account for the removal of emerging contaminants, allowing these pollutants to enter the environment [6]. Therefore, the purpose of this PhD is to determine effective strategies for the management of emerging contaminants in India, whilst also developing novel and sustainable treatment options for their removal. This study supports the Fate and Management of Emerging Contaminants (FAME) project, which is a major UK-India collaborative research project funded by the Natural Environment Research Council (NERC) UK and the Department of Science of Technology (DST) India. FAME aims to study the source and fate of emerging contaminants in India, and their interaction in receiving waters and wastewater treatment facilities. \nThe aim of the PhD is to develop a strategy for the management of emerging contaminants to improve water quality. This will be done by studying the sources and fate of emerging contaminants to better understand their interaction within the environment, receiving waters and wastewater treatment facilities. The aim will be achieved by answering research questions linked to the following objectives: \n1. A thorough review will be carried out on existing literature regarding emerging contaminants globally, with a specific focus on the UK, Europe and India. The review will explore existing management strategies for emerging contaminants posed in the literature to determine present approaches used in other countries. Additionally, the review will cover the fate of emerging contaminants in wastewater treatment plants and receiving waters, along with effective treatment techniques that are used to remove emerging contaminants; thereby reducing the concentration entering the environment. (What current research is being done to effectively manage emerging contaminants, thereby eliminating them from our water sources?)\n2. Using information collected from the review, novel and sustainable urban treatment solutions will be developed for the removal of emerging contaminants (Ciprofloxacin, Atenolol, Gemfibrozil, Diclofenac, Ibuprofen and Carbamazepine). A focus will be placed on using graphene adsorbents (porous graphene) to test the treatment efficiency and recovery potential of emerging contaminants. (Are graphene adsorbents a suitable low cost sustainable solution at effectively removing emerging contaminants?)\n3. Using secondary data collected from partner universities on the FAME project, along with primary data regarding removal methods, a decision support system will be created. The decision support system will allow for the selection of fit for purpose wastewater management strategies to improve water quality. (Can a decision support system allow for the effective management of emerging contaminants?)\n4. To publish and present findings from the work in papers and at conferences including a review pap
#> 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Nearly 60,000 women are diagnosed with breast cancer each year in the UK, and there are 12,000 deaths. Early diagnosis is key, with 90% of women diagnosed at the earliest stage surviving for at least five years, compared to 15% for women diagnosed with the most advanced stage. The focus of this research project, deep Raman spectroscopy, offers the possibility of real-time, in vivo diagnosis of breast cancer.\n\nRaman spectroscopy is an optical technique used to identify chemicals in a sample via inelastic scattering from vibrating molecules. Differences in the Raman signal from cancerous and normal tissue has already been used to identify early epithelial cancer, but until recently the technique has been limited to the tissue surface at depths of about 1 mm. Prof Stone's group has now demonstrated that by using deep Raman spectroscopy techniques depths of several centimetres may be probed, bringing subsurface cancers into range.\n\nWe wish to obtain a detailed, quantitative understanding of the sensitivity and specificity of Raman breast cancer diagnosis via state-of-the-art numerical simulations. The project will use software originally developed to model light transport through gas and dust in space, that has been adapted to model how light propagates through tissue. The code uses the Monte Carlo method, in which the illuminating radiation is modelled as a large number of photon packets, is ideally suited to highly scattering media such as human tissue.\n \nA key requirement for a reliable simulation is a realistic model for the optical properties of the scattering medium. The heterogeneous nature of tissue is usually simply described using multiple plane-parallel homogeneous layers. Our code, which combines triangular mesh surfaces with an adaptive Cartesian mesh, enables a much more sophisticated realization of the tissue's true three-dimensional structure.\n\nThe initial aim of this project is to implement Raman scattering physics into the code and validate this using extant experimental data. Subsequently a breast model will be constructed based on MRI data segmented to identify the different tissue types. This heterogeneous breast tissue model will provide an environment within which numerical experiments may be performed to quantify the sensitivity and specificity of Raman spectroscopy to varying tissue properties, cancer distributions, and probe geometries. The outputs from this project will feed back directly into the experimental work Prof Stone's group, with ultimate aim of establishing deep Raman spectroscopy as a routine diagnostic method in the clinical environment.
#> 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
#> 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at www.rcuk.ac.uk/StudentshipTerminology. Training grants may be to one organisation or to a consortia of research organisations. This portal will show the lead organisation only.
#> 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Waves on the sea or in the clouds are some of the most simple, yet beautiful, natural dynamic phenomena on Earth. They sometimes roll-up and form growing whirls. These phenomena occur due to a large flow difference at the transition between the air and water or cloud, which makes the boundary unstable. Similar instabilities also take place in space, when the filling plasma, a mixture of charged particles, is exposed to various sources of flows. The solar wind, for instance, is a continuous stream of plasma flowing away from the Sun. The magnetic field of the Earth forms a protective bubble called the magnetosphere, which is affected by large disturbances in the solar wind. The boundary between the solar wind and the magnetosphere is notably subject to large boundary motions. These motions may be the response to the changing force of the solar wind, like a fluttering windsock. They may also be growing whirls, that could involve a mixture of the two plasmas. In the solar wind, one can find massive clouds of material, called Coronal Mass Ejections (CMEs). CMEs are ejected from the solar atmosphere at hundreds of km per second, and are associated with outflows, another source of abrupt flow changes and instabilities. Very similar outflows are generated inside the magnetosphere. Space observations are challenging to analyse, the complexity of plasma physics makes them interesting to study and understand. I have long been fascinated by the natural world and its impact on us. The Sun affects life on Earth in many ways. Dangerous, high energy, charged particles are often produced in the CME disturbances. The magnetosphere shields us from most harmful solar effects. However, the large disturbances in the solar wind affect our climate and causes, for instance, communication drop-outs, power outages and radiation exposure on transatlantic flights. In the Sun's outer atmosphere, the solar corona, there are relatively cool, dense clouds of gas, which we call the solar prominences (or filaments). Prominences are in constant motion and display a relatively fast dynamic and turbulent flow system. Sometimes prominences erupt off the Sun, along with CMEs. From space, we can observe prominences night and day without interruption. Doing so, I have discovered prominences which oscillate quite slowly, so slowly that it is almost impossible to detect it continuously from Earth. The oscillations seem connected to prominence eruptions. Is there a link between the two types of dynamics, fast and slow? Is this link relevant to other flow instabilities in space? How are the prominences formed and why do they erupt? How is the solar wind accelerated? How does the solar wind get through the apparently closed field lines of the Earth's magnetic field? To find out, I propose to get a better picture of the flow instabilities in regions of the Sun-Earth system, where they seem to play a major role. All these phenomena are observed with a telescope or with a satellite measuring the plasma properties in space. Such observations present complementary perspectives. Their ever-increasing number and quality (e.g. Solar Dynamics Observatory) make it the right time to compare the phenomena, find their common features and their differences. I find it both exciting to develop a unifying view (combining my past experiences in both research fields) and important for our society to shed light on the processes at work in key regions of the Sun-Earth system.
#> 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 This proposal seeks funding to acquire a stepper and associated wafer coater, tools to enable photolithographic patterning of semiconductor wafers for device and circuit fabrication. The stepper will be located at Southampton University in the recent &pound;120m cleanroom complex. It will relieve the bottleneck within the cleanroom, an electron beam lithography tool, which is a slower alternative patterning tool. This will increase capacity within the cleanroom complex and facilitate and underpin a wealth of world class research. Not only will research at Southampton be enhanced, but Southampton (SOU), Glasgow (GLA), and Surrey (SUR) universities will pool resources to establish a Silicon Photonics Fabrication Capability within the UK, to facilitate an increasing demand for the fabrication of Silicon Photonics devices from the UK's premier researchers. This will encourage wider usage of world class equipment within the UK, in line with EPSRC policy. We seek funding for both the equipment and 3.5 RAs across the 3 institutions, over a 4 year period, to establish and deliver the Capability. Access to a very significant inventory of additional equipment at these 3 universities will be facilitated. The Capability is extremely timely, as silicon foundry services around the world are moving towards a model in which standard platforms and devices will be offered, making it more difficult for researchers to carry out innovative work at the device level, or in non-standard platforms.\n\nThe proposal is supported by 36 members of academic staff at Southampton, with a total current research portfolio of projects valued in excess of &pound;88m. Furthermore we have 10 project partners who will take part in the use and assessment of the silicon photonics capability by designing and subsequently testing fabricated devices. Their total in-kind contribution is valued at &pound;793,300. These partners have expressed an interest in using the capability after the project has been completed. In addition we have contacted a few example potential users from within the industrial sector (SMEs), and from around the world who have also provided letters of support indicating that they would use the capability after the project is complete. Taking this net proposed usage, it is clear that the equipment will be sustained beyond the period of the funded project. The Southampton users alone need only generate a tiny fraction (0.2%) of their research portfolio to cover running costs and depreciation. Consumables will increase with usage, but clearly, the silicon photonics capability will generate paying users, to further sustain the capability beyond the project, which will, in turn, allow UK researchers to compete effectively on the world stage in the buoyant field of silicon photonics. \n\nBeyond the 4 year project, the Silicon Photonics Capability will be operated by the commercial arms of the 3 partner universities, all of whom have provided letters of support confirming their ongoing participation.
#> 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                The FitzPatrick group use DNA sequencing technologies and advanced analytics to understand the causes of severe diseases affecting babies and children. They are particularly focussed on two groups of diseases. Firstly severe birth defects affecting both eyes (missing eyes, very small eyes, structurally abnormal eyes). The other group is children with severe intellectual disability and poor growth. They wish to understand how and why these disorders occur “out of the blue” and what are the underlying problems that occur to cells during development that results in the problems that are apparent at birth.
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#> 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <NA>
#> 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <NA>
#> 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                Alzheimer‘s disease (AD) is a common, heritable, genetically complex disorder. Genome-wide association studies (GWAS) have succeeded in identifying over 400 genetic variants contributing to complex phenotypes, in less than two years. Recently, our consortium performed a GWAS in 16,000 AD and control samples, which succeeded in identifying two new susceptibility genes (CLU: p= 8.5 x10-10, odds ratio (OR) = 0.86 &amp; PICALM: p= 1.3 x10-9, OR = 0.86), provided strong evidence for the existence of several more (13 variants observed p 1 x 10-5 , 4 expected by chance: p= 7.5 x 10-6)and confirmed a third susceptibility gene CR1. We will undertake a powerful GWAS (+55,000 individuals) of AD, aiming to identify 10 new susceptibility genes contributing to disease risk, modifying age at onset or contributing to copy number variation. Findings will be screened for AD susceptibility pathways and tested for relationships with clinical symptoms. This proposal will produce a definitive study of common genetic risk in AD and will deliver around 20 new susceptibility genes, CNVs and pathways in 2 years. Identifying new susceptibility genes will pinpoint primary causal pathways to disease and provide the basis for future preventative and therapeutic interventions, contribute to early susceptibility testing and increase UK research capacity.
#> 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <NA>
#> 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <NA>
#> 6  Scientific Abstract|AIM: The aim of this study is to determine if metformin, administered to obese women during pregnancy, reduces the future life risk of obesity and metabolic syndrome in their babies. We will use high birthweight centile as a surrogate marker for future life events as its validity has been shown in large epidemiological studies [1-3]. Secondly, we will use metformin administration as a tool to explore the mechanism by which obesity causes adverse pregnancy outcomes, with a particular focus on insulin resistance (IR). |DESIGN: Double blind placebo controlled randomised clinical trial. |SETTING: Antenatal clinics specialising in the care of obese pregnant women in two large maternity hospitals in the UK (Edinburgh and Liverpool). |TARGET POPULATION: Obese pregnant women.|INTERVENTIONS BEING EVALUATED: Metformin, an insulin sensitising agent or matched placebo initiated between 12 and 16 weeks gestation. |PRIMARY OUTCOMES: (i) Efficacy outcome - z-score corresponding to the gestational age and sex adjusted birthweight centiles of the baby (ii) Mechanistic outcome - maternal insulin resistance (IR) at 36 weeks gestation which will be correlated with adverse pregnancy outcomes. |SECONDARY OUTCOMES: (A) More detailed measurements of neonatal body composition at birth including ponderal index; skinfold thicknesses; and (Edinburgh babies only) neonatal fat mass measured using air displacement plethysmography. (B) Biological mechanisms of metformin action including (i) change in IR; hepatic and skeletal insulin sensitivity (ii) maternal and neonatal inflammatory and lipid indices including CRP, IL-6, leptin, lipids, triglycerides and PAI1/PAI2 ratio (iii) placental glucocorticoid receptor expression (iv) maternal brachial arterial endothelial dependent flow mediated dilatation (FMD) (v) in vitro measurements of maternal myometrial contractility [4] (vi) changes in maternal anthrometry. (C) Adverse pregnancy outcomes as a composite; incidence of low birthweight centile. (D) Gas chromatography mass spectrometry measurements of metformin in maternal plasma to determine compliance.|MEASUREMENT OF OUTCOME AND DURATION OF FOLLOW UP. Birthweight will be measured by clinical staff, the result prospectively transferred from the clinical birth record to a case report form and Z score of birthweight centile calculated using www.gestation.net. Maternal IR at 36 weeks gestation will be expressed as the Matsuda index [5] (the best correlate with the gold standard the hyperinsulinaemic euglycaemic clamp in pregnant women)[6], and derived from multiple sampling during a glucose tolerance test. Change in IR will be expressed as changes in a logarithmic and reciprocal transformation of a single fasting glucose and insulin value (QUICKI), measured during a glucose tolerance test at baseline (prior to treatment), at 28 weeks and at 36 weeks gestation [6]. |In a subgroup of women (n = 20 in each group) insulin resistance will be measured by the hyperinsulinaemic euglycaemic clamp, to characterise the relative effects of metformin on hepatic and peripheral skeletal muscle insulin sensitivity. Endothelial dependent FMD will be measured in a subset (n = 30 each group) at 36 weeks gestation using a non invasive, validated, and reproducible method suitable for use in pregnancy [7 8]. Initial follow up will cease once the woman and baby have been discharged postnatally, although we anticipate further funding applications to continue neonatal follow up into early childhood.|SAMPLE SIZE: |(1) BIRTHWEIGHT CENTILE. In a previous study, the mean (SD) birthweight in a cohort of obese women (mean BMI 34) was 4.0kg (0.6kg)[9]. We hypothesise that metformin will reduce mean birthweight by 200g, corresponding to a reduction in birthweight centile of 0.3 SD. We believe that this reduction in birthweight centile is clinically relevant, but is a relatively conservative estimate of likely reduction in birthweight centile induced by metformin, given that m
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#> 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <NA>
#> 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            <NA>
#> 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Our research group, led by David FitzPatrick, an academic paediatric geneticist, focuses on understanding the genetic basis of severe developmental disorders Major aims are identification of genetic causes of major eye malformations and a severe intellectual disability syndrome; Cornelia de Lange syndrome (CdLS). Following their discovery that a major cause of severe bilateral eye malformations is de novo formation of heterozygous, loss-of-function mutations in SOX2, they have used exome sequencing to identify several novel loci such as YAP1 and MAB21L2 for severe bilateral coloboma. They have also identified genetic changes in BRD4 as a novel cause of CdLS. A common theme of this work is the innovative use of genetic technologies to identify and validate causative mutations affecting the structure or regulation of individual genes. The major focus of the future work is the use of whole genome sequencing and cell and animal models to understand the impact of genetic changes in enhancers of dosage sensitive transcription factors in developmental disease. We have 3 major aims as follows:\n1) Identify and categorise highly penetrant genomic mutations causing human eye malformations using family-based whole genome sequencing (WGS) and whole exome sequencing (WES) with particular focus on interpreting changes in the noncoding genome\n2) Develop broadly applicable approaches to integrate the available clinical genomic data with quantitative (growth, developmental milestones) and categorical (HPO terms) phenotypic features to improve the diagnosis of known diseases and the discovery of new genes/genetic mechanisms.\n3) Define the functional genomic characteristics of the transitions in gene regulatory networks (GRN) driving very early eye development using in vitro (human embryonic stem cells differentiation) and in vivo (zebrafish embryogenesis) approaches both to improve our understanding of tissue-specific transcription factor function and to identify interpretable targets for non-coding mutations causing major eye malformations in the human genome.
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#> 1  The primary impact of this project will be on the ability of the Met Office to forecast high impact rainfall, and on downstream systems and users of those forecasts. \n\nProposed work on improving the quality and accuracy of radar reflectivity measurements and derived rainfall estimates will have impact in a number of ways. Firstly, there will be an immediate impact via the Met Office STEPS/UKPP numerical weather prediction (NWP) post-processing system. This objectively merges extrapolation forecasts with output from numerical weather prediction (currently the 1.5 km grid-spacing model, updated every 3 h, at best) to produce an 'optimal' forecast every hour. The output is used to drive hydrological models by the Environment Agency; in particular, it is used to drive the G2G model operated within the Joint Met Office/ Environment Agency Flood Forecasting Centre (FFC), which gives a national view of short-term flood risk, including un-gauged catchments. It is also used as guidance for the Extreme Rainfall Alerts, along with the UK convective-scale ensemble system, UK-MOGREPS. Improved radar-derived rainfall will also have a direct impact on the quality of the NWP forecast, as rainfall is assimilated and, incidentally, enable a more useful verification of any rainfall forecasts to be performed. \n\nLonger term improvements will come primarily through the implementation of a nowcasting configuration of the NWP system. This could become a replacement input into STEPS/UKPP and so naturally feed through to the same users. The Met Office have a key deliverable of their Public Weather Service R&amp;D plan to have an 'Operational implementation of next-generation NWP-nowcasting system' by March 2017. This would potentially include implementation of direct assimilation of radar reflectivity by 4DVAR rather than rainfall via latent heat nudging. This brings advantages of consistency and coupling to model dynamics, but will benefit enormously from the more accurate data, the better characterization of their errors and the more efficient use of data via improved representation of error covariance structure provided by this project. The latter will also have impact through better use of the information in the radar Doppler wind data and satellite observations already assimilated. \n \nThe NWP-based nowcasting system would also be the route through which the other main outputs of the project deliver impact, though they would also have impact in the existing NWP system if the nowcasting system were delayed. Use of radar refractivity provides a major source of low-level humidity information, vital for good forecasts of high-impact rainfall. This information is currently very sparse, mainly coming from surface synoptic stations but increasingly from aircraft as the land and take off from major airports. While we cannot predict the amount of forecast improvement, we know that deficiencies in low level moisture are a major contributor to forecast error.\n\nA better (and more adaptive) choice of moisture-variable(s) in the Data Assimilation system will have impact on the assimilation system, especially assimilation of refractivity and reflectivity (for which it may prove essential); this is a current goal in the Met Office's rolling plan for improvements.\n\nMany of these impacts will also have benefit for other forecast systems; techniques to model observation error covariance will be applicable in other systems and to other observation types. Application of refractivity will also be applicable in other radar systems.\n\nOf course, the ultimate aim of this project is impact on the public (and thus the insurance industry) through improved flood warnings, especially of pluvial and fluvial flooding of small, fast-response catchments. This will bring benefits through reduced loss of life and damage to property.
#> 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               <NA>
#> 9                       The impact of this strategic equipment grant lies in the new research that it will enable, and the range of technologies it will enhance. The research described in the Case for Support has wide-ranging impacts nationally and internationally in a number of important sectors, comprising the facilitation of high quality research by world leading groups that could fundamentally change those technologies and their exploitation. Furthermore, the introduction of a Silicon Photonics fabrication Capability within the UK will allow UK researchers to compete on the world-wide stage in this specific discipline, without having to rely on collaborators generosity, or to be limited to the &quot;standard&quot; devices and platforms that are developing in foundries both in Europe and the rest of the world. The list of UK universities providing letters of support is already impressive, and contains all of the leading silicon photonics groups in the UK, as well as other photonics activities that will utilise silicon photonics in some way. These groups represent the cream of the UK research community who are already operating world class activities. Their ability to utilise a &quot;local&quot; fabrication capability will enhance their effectiveness, and their productivity, and the impact of their work can only increase even more. Such impact will drive more publicity and hence additional users. Already the reaction from around the world is extremely positive.\n \nTo demonstrate this, we have invited selected additional potential users both from inside and from outside of the UK to write letters of support, indicating that they would utilise the Capability in the longer term. These include universities and SMEs. The purpose of these letters is to underline both the impact and the longer term viability of the proposed Capability. With foundry services moving away from device level research, there is a requirement to facilitate such work, in the way that some flexible foundry services have done until their move to standard platforms. This has established these foundries as international leaders in the field, and we anticipate a similar opportunity for a UK based Capability due to the dearth of alternative options for researchers to access, and hence this is a significant opportunity for the UK. Furthermore, We are now supported by Dr Andrew Rickman, the world's most successful Silicon Photonics entrepreneur. The existence of a flexible fabrication capability within the UK will be instrumental in Dr Rickman establishing his new venture within the UK, thus immediate impact is likely.\n\nAnother key part of our impact strategy is to enhance the diverse research within Southampton University. 36 members of academic staff (and their groups) support this bid. The introduction of the stepper will increase capacity in the Southampton cleanroom by releasing the pressure on the current bottleneck which is the electron-beam lithography system. Many of these researchers are already world leaders in their field, and the opportunity to be even more effective should not be missed, since their proven track record indicates the likelihood of success. The additional capacity will also inevitably result in new and additional research, enhancing the quality and volume of work at Southampton and in the UK. This will, in turn, allow enhanced training capability (RAs, undergraduates, MSc, and PhD students), more access to fabrication facilities for PhD students, and support of younger academics. Particularly important will be the emergence of the RAs employed on the project. They will be recognised as experts in the fields of device fabrication and silicon photonics, as has been observed in the example of RAs employed by the &quot;Epixfab&quot; foundry service.Their involvement will catapult them to prominence.
#> 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              <NA>
#>                                                                                                       healthCategory
#> 1                                                                                                               NULL
#> 2                                                                                                               NULL
#> 3                                                            041997EB-CFD8-493D-B0F8-DFA35451D0BE, Neurological, 100
#> 4                                                                                                               NULL
#> 5                                                                                                               NULL
#> 6                                      FA7AA693-7EDD-4A7E-8CA3-6B5658FBF717, Reproductive Health and Childbirth, 100
#> 7                                                                                                               NULL
#> 8                                                                                                               NULL
#> 9                                                                                                               NULL
#> 10 A9061818-9B1E-495A-9617-7C77200827C2, F3822669-BB5A-4BB4-BAE0-DCB9DE36E092, Eye, Generic Health Relevance, 50, 50
#>                                                                                                                                                                  researchActivity
#> 1                                                                                                                                                                            NULL
#> 2                                                                                                                                                                            NULL
#> 3                                                                                               1BF330A9-C7B5-49C5-B54B-CF4FAE6DF1D8, 2.1  Biological and endogenous factors, 100
#> 4                                                                                                                                                                            NULL
#> 5                                                                                                                                                                            NULL
#> 6                                                                                                                 7135039D-2DB0-4D41-87B3-FA1C8D38E133, 6.1  Pharmaceuticals, 100
#> 7                                                                                                                                                                            NULL
#> 8                                                                                                                                                                            NULL
#> 9                                                                                                                                                                            NULL
#> 10 1BF330A9-C7B5-49C5-B54B-CF4FAE6DF1D8, CF950C9A-DB16-4E23-8AEB-94548777BCA1, 2.1  Biological and endogenous factors, 1.1  Normal biological development and functioning, 50, 50
#>                                                                                                                                                                                                      researchSubject
#> 1  FB535BD0-E265-4C0A-8532-32DCB83A3951, E4C03353-6311-43F9-9204-CFC2536D2017, DEA11FBC-BEED-4EDD-890B-97D728462D26, Tools, technologies & methods, Atmospheric phys. & chemistry, Mathematical sciences, 25, 65, 10
#> 2                                                                                          6723A70B-A523-40AB-9740-B6AD2A0677B7, 972C8509-5001-4523-9E10-7FA67E2F2E69, Medical & health interface, Visual arts, 0, 0
#> 3                                                                                                                                                                                                               NULL
#> 4                                                                                                                                                                                                               NULL
#> 5                                                                                                                                                                                                               NULL
#> 6                                                                                                                                                                                                               NULL
#> 7                                                                                                                                                                                                               NULL
#> 8                                                                                                                                                                                                               NULL
#> 9                                                                                 D513F43E-F19D-4AB3-8E03-A47B085709AB, EB5F16BB-2772-4DDE-BD6C-3B7A6914B64C, Materials Processing, Info. & commun. Technol., 10, 90
#> 10                                                                                                                                                                                                              NULL
#>                                                                                                                                                                                                                                                                                                                                     researchTopic
#> 1  CFBD6626-50CB-4AA6-8B49-9A76519BA91F, AE661B5A-7390-4AD2-BCF2-D611CB668BD1, C62D281D-F1B9-423D-BDAB-361EC9BE7C68, 4504C6B4-D825-4F14-B0D3-7931AC636B71, B01D3878-E7BD-4830-9503-2F54544E809E, Numerical Analysis, Tropospheric Processes, Water In The Atmosphere, Remote Sensing & Earth Obs., Boundary Layer Meteorology, 10, 10, 30, 25, 25
#> 2                                                                                                                                                      EFFEC6B1-6BC8-4C9D-9D77-02CEF5E4E301, 62F4842F-55F4-41C6-A77A-572005E91429, 3C193D18-12BD-4B15-8347-037BA623E0FF, Biomedical neuroscience, Community Art inc A & H, Mental Health, 0, 0, 0
#> 3                                                                                                                                                                                                                                                                                                                                            NULL
#> 4                                                                                                                                                                                                                                                                                          D05BC2E0-0345-4A3F-8C3F-775BC42A0819, Unclassified, NA
#> 5                                                                                                                                                                                                                                                                                          D05BC2E0-0345-4A3F-8C3F-775BC42A0819, Unclassified, NA
#> 6                                                                                                                                                                                                                                                                                                                                            NULL
#> 7                                                                                                                                                                                                                                                                                          D05BC2E0-0345-4A3F-8C3F-775BC42A0819, Unclassified, NA
#> 8                                                                                                                                                                                                                                                                                          D05BC2E0-0345-4A3F-8C3F-775BC42A0819, Unclassified, NA
#> 9                                                                                                                                 66CE6BAB-875D-4F4D-B415-F93CA7A2C4CA, D513F43E-F19D-4AB3-8E03-A47B085709AB, D200E827-7353-47BA-BA02-0446908D46FB, Optical Devices & Subsystems, Materials Processing, Optoelect. Devices & Circuits, 45, 10, 45
#> 10                                                                                                                                                                                                                                                                                                                                           NULL
#>    rcukProgramme start end participantValues
#> 1           NULL    NA  NA                NA
#> 2           NULL    NA  NA                NA
#> 3           NULL    NA  NA                NA
#> 4           NULL    NA  NA                NA
#> 5           NULL    NA  NA                NA
#> 6           NULL    NA  NA                NA
#> 7           NULL    NA  NA                NA
#> 8           NULL    NA  NA                NA
#> 9           NULL    NA  NA                NA
#> 10          NULL    NA  NA                NA